Endocrine Abstracts

Background: It is recognised that the incidence of type 1 diabetes mellitus (T1DM) is increasing in the United Kingdom, especially in young patients (<5 y). Although seasonal variation in the onset of T1DM, with autumn and winter peaks, and also in the month of birth has been described, it was our perception that new patients were presenting throughout the year to our unit.Methods: Data was available on 440 newly diagnosed cases of TIDM, (100, 173 an...

Type 1 pseudohypoaldosteronism (PHA1), defined as resistance to aldosterone, is characterised by salt wasting, hyperkalemia and metabolic acidosis and is associated with high renin and aldosterone levels. The autosomal recessive form is characterised by generalised salt wasting and is due to a defect in the epithelial sodium channel. Whilst there are individual case reports on this condition, there are little published data on long-term outcome including neurodevelopment.<...